Purpose:- Uncertainties in manufacturing and changing customer demands force manufacturing industries to adopt new strategies, such as the Reconfigurable Manufacturing System (RMS). To improve the implementation and performance of RMS, it is necessary to review the available literature and identify future trends in this field. This paper aims to analyze existing literature and to see trends in RMS-related research. Design/Methodology/Approach:- The systematic literature review and analysis of RMS-related research papers from 1999 to 2020 is carried out in this literature. The selected articles are analyzed based on the year of publication, journals, publishers, active authors, research design, countries, enablers, barriers, performance evaluation parameters, and universities. Findings:- After the analysis of selected RMS-related research papers, the top countries, universities, journals, publishers, and authors are identified in this domain. Research themes and trends in research are identified in this study. Besides, it has been noted that there is a need for further research in this domain and for the creation of a generalized framework that can guide researchers and practitioners to increase RMS adoption. Practical Implications:- Research insights, guidance, and observations from this paper are provided to RMS-related researchers and practitioners. Important research gaps are identified in this article, which can provide direction for future research as well as trends in RMS research. Originality/Value:- The study presented focuses mainly on the method of collecting, organizing, capturing, interpreting, and analyzing data to provide more insight into RMS to identify future trends in research.