Purpose – Because of the COVID-19 pandemic and changing market demands, competition for manufacturing industries is increasing and they face numerous challenges. In such a case, it is necessary to use multiple strategies, technologies and practices to improve organizational performance and, as a result, to integrate them for ease of adoption. The purpose of this research is to identify advanced Industry 4.0 technologies, operational excellence (OPEX) strategies and reconfigurable manufacturing system (RMS) practices. The study also computes their weights, as well as identifies and prioritizes the performance metrics for the same. Design/methodology/approach – A thorough review of relevant articles was conducted to identify 28 OPEX strategies, RMS practices and advanced technologies, as well as the 17-performance metrics. The stepwise weight assessment ratio analysis approach was used to compute the weights of the selected practices, while the WASPAS approach was used to prioritize the performance metrics. While developing the framework, the industry expert’s expertise was incorporated in the form of their opinions for pairwise comparison. Findings – According to the study findings, advanced Industry 4.0 technologies were the most prominent for improving organizational performance. As a result, integrating Industry 4.0 technologies with OPEX strategies can assist in improving the performance of manufacturing organizations. The prioritized performance metrics resulted in the production lead time ranking first and the use of advanced technologies ranking second. This emphasizes the significance of meeting dynamic customer needs on time while also improving quality with the help of advanced technologies. Practical implications – The developed framework can help practitioners integrate OPEX strategies and advanced technologies into their organizations by adopting them in order of importance. Furthermore, the ranked performance metrics can assist managers and practitioner