Purpose A reconfigurable manufacturing system (RMS) can provide manufacturing flexibility, meet changing market demands and deliver high performance, among other benefits. However, adoption and performance improvement are critical activities in it. The current study aims to identify the important factors influencing RMS adoption and validate a conceptual model as well as develop a structural model for the identified factors. Design/methodology/approach An extensive review of RMS articles was conducted to identify the eight factors and 47 sub-factors that are relevant to RMS adoption and performance improvement. For these factors, a conceptual framework was developed as well as research hypotheses were framed. A questionnaire was developed, and 117 responses from national and international domain experts were collected. To validate the developed framework and test the research hypothesis, structural equation modeling was used, with software tools SPSS and AMOS. Findings The findings support six hypotheses: “advanced technologies,” “quality and safety practice,” “strategy and policy practice,” “organizational practices,” “process management practices,” and “soft computing practices.” All of the supported hypotheses have a positive impact on RMS adoption. However, the two more positive hypotheses, namely, “sustainability practices” and “human resource policies,” were not supported in the analysis, highlighting the need for greater awareness of them in the manufacturing community. Research limitations/implications The current study is limited to the 47 identified factors; however, these factors can be further explored and more sub-factors identified, which are not taken into account in this study. Practical implications Managers and practitioners can use the current work’s findings to develop effective RMS implementation strategies. The results can also be used to improve the manufacturing system’s performance and identify the source of poor performance.