Purpose Agile new product development (ANPD) attracts researchers and practitioners by its ability to rapidly reconfigure products and related processes to meet the needs of emerging markets. To increase ANPD adoption, this study aims to identify ANPD enablers (ANPDEs) and create a structural framework that practitioners can use as a quick reference. Design/methodology/approach Initially, a comprehensive literature review is conducted to identify ANPDEs, and a structural framework is developed in consultation with an expert panel using a hybrid robust best–worst method interpretive structural modeling (ISM). During the ISM process, the interactions between the ANPDEs are investigated. The ISM result is used as input for fuzzy Matrice d’Impacts croises-multiplication appliqúean classment means cross-impact matrix multiplication applied to classification (MICMAC) analysis to investigate enablers that are both strong drivers and highly dependent. Findings The study’s findings show that four ANPDEs are in the low-intensity cluster and thus are excluded during the structural frame development. ISM output shows that “Strong commitment to NPD/top management support,” “Availability of resources,” “Supplier commitment/capability” and “Systematic project planning” are the important ANPDEs. Based on their driving and dependence power, the clusters formed during the fuzzy MICMAC approach show that 16 ANPDEs appear in the dependent zone, one ANPDE in the linkage zone and 14 ANPDEs in the driving zone. Practical implications This research has intense functional consequences for researchers and practitioners within the industry. Industry professionals require a conservative focus on the established ANPDEs during ANPD adoption. Management has to carefully prepare a course of action to avoid any flop during ANPD adoption. Originality/value The framework established is a one-of-a-kind study that provides an integrated impression of important ANPDEs.